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Associate

Hyo-Joong Kim

Education

  • BS in Chemistry Education. Seoul National University, South Korea (1991)
  • MS in Chemistry. Seoul National University, South Korea (1993)
  • PhD in Chemistry. University of Alabama, Tuscaloosa, AL (2004)
  • Postdoctoral Research Associate. University of Georgia, Athens, GA (2004-2006)

Research summary

Darwinian Chemistry. RNA is thought to be the only genetic material on early Earth until DNA emerged. I am trying to get an RNA molecule that catalyzes the template-directed synthesis of RNA.

Dynamic Combinatorial Chemistry. Detection of specific nucleic acid sequence in complex genomic mixture is an important area. For this goal, I am using two oligonucleotide primers which can bind reversibly each other at the end of their sequence. These segmented primers are expected to prime in the presence of the target sequence without mismatch problem.

Recent Publications

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Catalytic Synthesis of Polyribonucleic Acid on Prebiotic Rock Glasses
Craig A. Jerome, Hyo-Joong Kim, Stephen J. Mojzsis, Steven A. Benner, and Elisa Biondi
Astrobiology (2022) http://doi.org/10.1089/ast.2022.0027
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Abiotic Synthesis of Nucleoside 5'-Triphosphates with Nickel Borate and Cyclic Trimetaphosphate (CTMP)
Kim, H.J.., Benner, S.A.
Astrobiology (2021) 21(3), DOI:10.1089/ast.2020.2264
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When Did Life Likely Emerge on Earth in an RNA-First Process?
S. A. Benner, E. A. Bell, E. Biondi, R. Brasser, T. Carell, H.-J. Kim, S. J. Mojzsis, A. Omran, M. A. Pasek, D. Trail
ChemSystemsChem 2 , Chemistry Europe (2020) e1900035
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Chemical guidance in the search for past and extant life on Mars. Decadal Survey in Planetary Sciences and Astrobiology
Benner, S. A., Biondi, E., Kim, H.-J., Spacek, J.
Bulletin of the AAS , AAS (2020) 53(4), DOI:10.3847/25c2cfeb.266df7e7
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Hachimoji DNA and RNA: A genetic system with eight building blocks
Hoshika H, Leal N, Kim MJ, Kim MS, Karalkar NB, Kim HJ, Bates AM, Watkins Jr. NE, SantaLucia HA, Meyer AJ, DasGupta S, Piccirilli JA, Ellington AD, SantaLucia Jr. J, Georgiadis MM, Benner SA
Science (2019) 22 Feb 2019: Vol. 363, Issue 6429, pp. 884-887. DOI: 10.1126/science.aat0971
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Prebiotic Chemistry that Could Not Not Have Happened
Benner S.A., Kim H.-J., and Biondi E.
Life 9 (4) , MDPI 84 (2019) https://doi.org/10.3390/life9040084
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Hydroxymethanesulfonate from volcanic sulfur dioxide. A mineral reservoir for formaldehyde in prebiotic chemistry.
Kawai, J., McLendon, D.C., Kim, H.-J., Benner, S.A.
Astrobiology (2019) 19(4):506-516, DOI:10.1089/ast.2017.1800
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A Prebiotic Synthesis of Canonical Pyrimidine and Purine Ribonucleotides
Kim, H.-J., Kim, J.
Astrobiology (2019) 19(5):669-74, DOI:10.1089/ast.2018.1935
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A Direct Prebiotic Synthesis of Nicotinamide Nucleotide
Hyo-Joong Kim, Steven A. Benner
Chemistry , Wiley-VCH (2018) Jan 12;24(3):581-584. doi: 10.1002/chem.201705394
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Mineral-Organic Interactions in Prebiotic Synthesis. The Discontinuous Synthesis Model for the Formation of RNA in Naturally Complex Geological Environments.
Steven A. Benner, Hyo-Joong Kim, and Elisa Biondi
Nucl. Acids & Mol. Bio. 35 , Springer 31-83 (2018) https://doi.org/10.1007/978-3-319-93584-3_3
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